<p>Primary Generalized Glucocorticoid Hypersensitivity Treated with Mifepristone: A Case Report</p>
نویسندگان
چکیده
منابع مشابه
Primary generalized glucocorticoid resistance and hypersensitivity.
CONTEXT The human glucocorticoid receptor (hGR) is a ubiquitously expressed intracellular, ligand-dependent transcription factor, which mediates the action of glucocorticoids and influences physiological functions essential for life. Alterations in the molecular mechanisms of hGR action impair glucocorticoid signal transduction and alter tissue sensitivity to glucocorticoids. This review summar...
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Abstract Background: Alendronate is a bisphosphonate that is approved to reduce bone loss in glucocorticoid treated patients. In this paper, we present a case of femoral fracture following the use of Alendronate. Case presentation: A- 46 year old woman who was a known case of hemolytic anemia has been treated by prednisolone (with different doses from 7.5 to 75 mg/day), calcium-D 500 mg/day a...
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Proopiomelanocortin (POMC) deficiency causes severe obesity through hyperphagia of hypothalamic origin. However, low glucocorticoid levels caused by adrenal insufficiency mitigate against insulin resistance, hyperphagia and fat accretion in Pomc-/- mice. Upon exogenous glucocorticoid replacement, corticosterone-supplemented (CORT) Pomc-/- mice show exaggerated responses, including excessive fat...
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OBJECTIVE Mifepristone, a glucocorticoid receptor antagonist, improves clinical status in patients with Cushing's syndrome (CS). We examined the pattern, reliability and correlates of global clinical response (GCR) assessments during a 6-month clinical trial of mifepristone in CS. DESIGN Post hoc analysis of secondary end-point data from a 24-week multicentre, open-label trial of mifepristone...
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CASE REPORT A 26-year-old woman of Vietnamese descent presented to the emergency department with a widespread, symmetric, erythematous, and pustular eruption (Fig 1). The outbreak initially affected the waistline, and the axillary, inguinal, and inframammary folds. It then spread to involve the neck, wrists, areolae, and the antecubital and popliteal fossae (Fig 2). The pustules were superficia...
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ژورنال
عنوان ژورنال: International Journal of General Medicine
سال: 2020
ISSN: 1178-7074
DOI: 10.2147/ijgm.s273969